Kaplan,
C. D., Holland, M. J., Winston, F. 2005. Interaction between transcription
elongation factors and mRNA 3'-end formation at the Saccharomyces cerevisiae
GAL10-GAL7 locus.
J.
Biol. Chem. 280: p. 913-922.
Larschan E. and Winston F. The Saccharomyces cerevisiae Srb8-Srb11 complex functions with the SAGA complex during Gal4-activated transcription. Mol Cell Biol. 2005 Jan;25(1):114-23.
Dror, V. and Winston, F. 2004. The Swi/Snf chromatin remodeling complex is required for rDNA and telomeric silencing in Saccharomyces cerevisiae. Mol. Cell. Biol. 24: 8227-8235.
Martens, J.A.,
Laprade, L., and Winston, F. 2004. Intergenic transcription is required
to repress the S. cerevisiae SER3 gene. Nature
429: 571-574.
Wu. P.-Y. J., Ruhlman, C., Winston, F., and Schultz, P. 2004. Molecular
architecture of the S. cerevisiae SAGA complex. Mol.
Cell 15: 199-208.
Hess, D., Liu,
B., Roan, N.R., Sternglanz, R., Winston, F. 2004. Spt10-dependent transcriptional
activation in S. cerevisiae requires both the Spt10 acetyltransferase
domain and Spt21. Mol.
Cell. Biol. 24: 135-143.
Duina, A., Winston, F. 2004. Analysis of a histone H3 mutant that perturbs
association of Swi/Snf with chromatin. Mol.
Cell. Biol. 24: 561-572.
Kaplan CD, Laprade L, Winston F.2003. Transcription elongation factors repress transcription initiation from cryptic sites. Science 301: 1096-1099.
Martens JA, Winston F. 2002. Evidence that Swi/Snf directly represses transcription in S. cerevisiae. Genes Dev 16: 2231-6
Hongay C, Jia N, Bard M, Winston F. 2002. Mot3 is a transcriptional repressor of ergosterol biosynthetic genes and is required for normal vacuolar function in Saccharomyces cerevisiae. EMBO 21:4114-24
Wu PY, Winston F. 2002. Analysis of Spt7 Function in the Saccharomyces cerevisiae SAGA Coactivator Complex. Mol Cell Biol 22:5367-79
Laprade L, Boyartchuk
VL, Dietrich WF, Winston F. 2002. Spt3 Plays Opposite Roles in Filamentous
Growth in Saccharomyces cerevisiae and Candida albicans and Is Required
for C. albicans Virulence. Genetics
161:509-19
Bryk M, Briggs SD, Strahl BD, Curcio MJ, Allis CD, Winston F. 2002. Evidence
that Set1, a Factor Required for Methylation of Histone H3, Regulates
rDNA Silencing in S. cerevisiae by a Sir2-Independent Mechanism. Curr
Biol. 12(2):165-70.
Larschan, E. and Winston, F. 2001. The S. cerevisiae SAGA complex functions in vivo as a coactivator for transcriptional activation by Gal4. Genes & Dev. 15: 1946-1956.
Zhou, H. and Winston, F. 2001. NRG1 is required for glucose repression of the SUC2 and GAL genes of Saccharomyces cerevisiae. BMC Genetics 2: 5.
Kaplan, C.D., Morris, J.R., Wu, C.-t., and Winston, F. 2000. Spt5 and Spt6 are associated with active transcription and have characteristics of general elongation factors in Drosophila melanogaster. Genes & Dev. 14: 2623-2634.
Lee, T. I., Causton, H. C., Holstege, F. C. P., Shen, W.-C., Hannett, N., Jennings, E. G., Winston, F., Green, M. R., and Young, R. A. 2000. Redundant roles for SAGA and TFIID in global transcription. Nature 405: 701-704.
Pinto, I. and Winston, F. 2000. Histone H2A is required for normal centromere function in Saccharomyces cerevisiae. EMBO J. 7: 1598-1612.
Sudarsanam, P., Iyer, V., Brown., P.O., and Winston, F. 2000. Whole-genome expression analysis of snf/swi mutants of S. cerevisiae. Proc. Natl. Acad. Sci. USA 97: 3364-3369.
Dudley, A. M., Rougeulle, C.,
and Winston, F. 1999. The Spt components of SAGA facilitate TBP binding
to a promoter at a post-activator- binding step in vivo. Genes
& Dev. 13: 2940-2945.
Cairns, B. R., Schlichter, A., Erdjument-Bromage, H., Tempst, P., Kornberg,
R. D., and Winston, F. 1999. Two functionally distinct forms of the RSC
nucleosome- remodeling complex, containing essential AT-hook, BAH, and
bromodomains. Mol.
Cell 4: 715-723.
Natarajan, K., Jackson, B. M., Zhou, H., Winston, F., and Hinnebusch,
A. G. 1999. Transcriptional activation by Gcn4p involves independent interactions
with SWI/SNF complex and SRB/Mediator.
Mol. Cell 4: 657-664.
Sudarsanam, P., Cao, Y., Wu, L, Laurent, B. C., and Winston, F. 1999.
The nucleosome remodeling complex, Snf/Swi, is required for the maintenance
of transcription in vivo and is partially redundant with the histone
acetyltransferase, Gcn5. EMBO
J. 18: 3101- 3106.
Dudley, A. M., Gansheroff, L. J., and Winston, F. 1999. Specific components
of the SAGA complex are required for Gcn4- and Gcr1-mediated activation
of the his4-912delta promoter in S. cerevisiae.
Genetics 151: 1365-1378.
Sterner, D. E., Grant, P.A., Roberts, S. M., Duggan, L. J., Belotserkovskaya,
R., Pacella, L. A., Winston, F., Workman, J. L., and Berger, S. L. 1999.
Functional organization of the yeast SAGA complex: Distinct components
involved in structural integrity, nucleosome acetylation, and TBP binding.
Mol.
Cell. Biol. 19: 86-98.
Cairns, B.R., Erdjument-Bromage, H., Tempst, P., Winston, F., and Kornberg,
R.D. 1998. Two actin-related proteins are shared functional components
of the chromatin remodeling complexes RSC and SWI/SNF. Mol.
Cell 2: 639-651.
Yu, J., Madison, J.M., Mundlos, S., Winston, F., and Olsen, B.R. 1998.
Characterization of a human homologue of the S. cerevisiae transcription
factor Spt3. Genomics
53: 90-96.
Madison, J.M., Dudley, A.M., and Winston, F. 1998. Identification and
analysis of Mot3, a zinc-finger protein that binds to the retrotransposon
Ty LTR (delta) in Saccharomyces cerevisiae.
Mol. Cell. Biol. 18: 1879-1890.
Hartzog, G.A., Wada, T., Handa, H., and Winston, F. 1998. Evidence that
Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase
II in Saccharomyces cerevisiae. Genes
& Dev. 12: 357-369.
Wada, T., Takagi, T., Yamaguchi, Y., Ferdous, A., Imai, T., Hirose, S.,Sugimoto,
S., Yano, K., Hartzog, G.A., Winston, F., Buratowski, S., and Handa, H.
1998. DSIF, a novel transcription elongation factor that regulates RNA
polymerase II processivity, is composed of human Spt4 and Spt5 homologs.
Genes & Dev. 12: 343-356.
Madison, J.M. and Winston, F. 1998. Identification and analysis of homologues
of Saccharomyces cerevisiae Spt3 suggest conserved functional
domains. Yeast
14: 409-417.
Wu, L. and Winston, F. 1997. Evidence that Snf/Swi controls chromatin
structure over both the TATA and UAS regions of the SUC2 promoter in Saccharomyces
cerevisiae, Nucl.
Acids. Res. 25: 4230-4234
Roberts, S.M., and Winston, F. 1997. Essential functional interactions
of SAGA, a Saccharomyces cerevisiae complex of Spt, Ada,
and Gcn5 proteins, with the Snf/Swi and Srb/mediator complexes.
Genetics 147: 451-465.
Grant, P.A., Duggan, L., Côté, J., Roberts, S.M., Brownell,
J, Candau, R., Ohba, R., Owen-Hughes, T., Allis, C.D., Winston, F., Berger,
S.L., and Workman, J.L. 1997. Yeast Gcn5 functions in two multisubunit
complexes to acetylate nucleosomal histones: characterization of an ADA
complex and the SAGA (Spt/Ada) complex. Genes
& Dev. 11: 1640-1650
Madison, J.M., and Winston, F. 1997. Evidence that Spt3 functionally interacts
with Mot1, TFIIA, and TBP to confer promoter-specific transcriptional
control in Saccharomyces cerevisiae. Mol.
Cell. Biol. 17: 287-295.
Bortvin, A., and Winston, F. 1996. Evidence that Spt6p controls chromatin
structure by a direct interaction with histones. Science
272: 1473-1476.
Roberts, S.M. and Winston, F. 1996. SPT20/ADA5 encodes a novel
protein functionally related to the TATA-binding protein and important
for transcription in Saccharomyces cerevisiae. Mol.
Cell. Biol 16: 3206-3213
Hartzog, G.A., Basrai, M.A., Ricupero-Hovasse, S.L., Hieter, P., and Winston,
F. 1996. Identification and analysis of a functional human homologue of
the SPT4 gene of Saccharomyces cerevisiae. Mol.
Cell. Biol.16: 2848-2856.
Arndt, K.M., Ricupero-Hovasse, S.L., and Winston, F. 1995. TBP mutants
defective in activated transcription in vivo. EMBO
J.14: 1490-1497.
Hirschhorn, J.N., Bortvin, A.L., Ricupero-Hovasse, S., and Winston, F.
1995. A new class of histone H2A mutations in Saccharomyces cerevisiae
causes specific transcriptional defects in vivo.Mol.
Cell. Biol.15: 1999-2009.
Gansheroff, L.J., Dollard, C., Tan, P., and Winston, F. 1995. The Saccharomyces
cerevisiae SPT7 gene encodes a very acidic protein important for transcription
in vivo. Genetics
139: 523-536.
Winston, F., Dollard, C., and Ricupero-Hovasse, S.L. 1995. Construction
of a set of convenient Saccharomyces cerevisiae strains that are
isogenic to S288C. Yeast
11: 53-55.
Dollard, C., Ricupero-Hovasse, S.L., Natsoulis, G., Boeke, J.D., and Winston,
F. 1994. SPT10 and SPT21 are required for transcription
of particular histone genes in Saccharomyces cerevisiae. Mol.
Cell. Biol.14: 5223-5228.
Eisenmann, D.M., Chapon, C. Roberts, S.M., Dollard, C. and Winston. F.
1994. The S. cerevisiae SPT8 gene encodes a very acidic
protein that is functionally related to SPT3 and TATA-binding protein.
Genetics
137: 647-657.
Arndt, K.M., Wobbe, C.R., Ricupero-Hovasse, S., Struhl, K., and Winston,
F. 1994. Equivalent mutations in the two repeats of yeast TATA-binding
protein confer distinct TATA- recognition specificities.Mol.
Cell. Biol. 14: 3719-3728.
Natsoulis, G., Winston, F., and Boeke, J.D. 1994. The SPT10 and
SPT21 genes of Saccharomyces cerevisiae. Genetics
136: 93-105.
Prelich, G. and Winston. F. 1993. Mutations that suppress the deletion
of an upstream activating sequence in yeast: involvement of a protein
kinase and histone H3 in repressing transcription in vivo. Genetics
135: 665-676.
Malone, E.A., Fassler, J.S., and Winston, F. 1993. Molecular and genetic
characterization of SPT4, a gene important in transcription initiation
in Saccharomyces cerevisiae.
Mol. Gen. Genet. 237: 449-459.
Hirschhorn, J.N., Brown, S.A., Clark, C.D., and Winston, F. 1992. Evidence
that SNF2/SWI2 and SNF5 activate transcription in yeast by altering chromatin
structure. Genes
& Dev. 6: 2288-2298.
Happel, A.M. and Winston, F. 1992. A mutant tRNA affects delta-mediated
transcription in Saccharomyces cerevisiae. Genetics
132: 361-374.
Swanson, M.S. and Winston, F. 1992. SPT4, SPT5, and SPT6
interactions: effects on transcription and viability in Saccharomyces
cerevisiae. Genetics
132: 325-336.
Haynes, S.R., Dollard, C., Winston, F., Beck, S., Trowsdale, J., and Dawid,
I.B. 1992. The bromodomain: a conserved sequence found in human, Drosophila
and yeast proteins.
Nuc. Acids Res. 20: 2603-2603.
Eisenmann, D.M., Arndt, K.M., Ricupero, S.L., Rooney, J.W., and Winston,
F. 1992. SPT3 interacts with TFIID to allow normal transcription in Saccharomyces
cerevisiae. Genes
& Dev. 6: 1319-1331.
Arndt, K.M., Ricupero, S.L., Eisenmann, D.M., and Winston, F. 1992. Biochemical
and genetic characterization of a yeast TFIID mutant that alters transcription
in vivo and DNA binding in vitro. Mol.
Cell. Biol. 12: 2372-2382.
Natsoulis, G., Dollard, C., Winston, F., and Boeke, J.D. 1991. The products
of the SPT10 and SPT21 genes of Saccharomyces cerevisiae
increase the amplitude of transcriptional regulation at a large number
of unlinked loci. New
Biologist 3: 1249-1259.
Malone, E.A., Clark, C.D., Chiang, A., and Winston, F. 1991. Mutations
in SPT16/CDC68 suppress cis- and trans-acting mutations
that affect promoter function in Saccharomyces cerevisiae.
Mol. Cell. Biol. 11: 5710-5717.
Swanson, M.S., Malone, E.A., and Winston, F. 1991. SPT5, an essential
gene important for normal transcription in Saccharomyces cerevisiae,
encodes an acidic nuclear protein with a carboxy-terminal repeat. Mol.
Cell. Biol. 11: 3009-3019.
Happel, A.M., Swanson, M.S., and Winston, F. 1991. The SNF2, SNF5,
and SNF6 genes are required for Ty transcription in Saccharomyces
cerevisiae.
Genetics 128: 69-77.
Hoffman, C.S., and Winston, F. 1991. Glucose repression of transcription
of the Schizosaccharomyces pombe fbp1 gene occurs by a cAMP signaling
pathway. Genes
& Dev. 5: 561-671.
Swanson, M.S., Carlson, M., and Winston, F. 1990. SPT6, an essential
gene that affects transcription in Saccharomyces cerevisiae, encodes
a nuclear protein with an extremely acidic amino terminus. Mol.
Cell. Biol. 10: 4935-4941.
Fikes, J.D., Becker, D.M., Winston, F., and Guarente, L. 1990. Striking
conservation of TFIID in Schizosaccharomyces pombe and Saccharomyces
cerevisiae. Nature
346: 291-294.
Walker, J., Chen, T.A., Sterner, R., Berger, M., Winston, F. and Allfrey,
V.G. 1990. Affinity chromatography of mammalian and yeast nucleosomes.
Two modes of binding of transcriptionally active mammalian nucleosomes
to organomercurial-agarose columns, and contrasting behavior of the active
nucleosomes of yeast.
J.
Biol. Chem. 265: 5736-5746.
Hoffman, C.S., and Winston, F. 1990. Isolation and characterization of
mutants constitutive for expression of the fbp1 gene of Schizosaccharomyces
pombe. Genetics
124: 807- 816.
Fassler, J.S., and Winston, F. 1989. The Saccharomyces cerevisiae
SPT13/GAL11 gene has both positive and negative regulatory roles
in transcription. Mol.
Cell. Biol. 9: 5602-5609.
Hoffman, C.S., and Winston, F. 1989. A transcriptionally regulated expression
vector for the fission yeast, Schizosaccharomyces pombe.
Gene 84: 473-479.
Eisenmann, D.M., Dollard, C., and Winston, F. 1989. SPT15, the
gene encoding the yeast TATA-binding factor TFIID, is required for normal
transcription initiation in vivo.
Cell 58: 1183-1191.
Natsoulis, G., Thomas, W., Roghmann, M.-C., Winston, F. and Boeke, J.
1989. Transposition in Saccharomyces cerevisiae is non-random.
Genetics
123: 269-279.
Hirschman, J.E., Durbin, K.J. and Winston, F. 1988. Genetic evidence for
promoter competition in Saccharomyces cerevisiae. Mol.
Cell. Biol. 8: 4608-4615.
Clark-Adams, C.D., Norris, D., Osley, M.A., Fassler, J.S. and Winston,
F. 1988. Changes in histone gene dosage alter transcription in yeast.
Genes
& Dev. 2: 150-159.
Hirschhorn, J.N. and Winston, F. 1988. SPT3 is required for normal levels
of a-factor and alpha-factor expression in Saccharomyces cerevisiae.
Mol.
Cell. Biol. 8: 822-827.
Fassler, J.S. and Winston, F. 1988. Isolation and analysis of a novel
class of suppressor of Ty insertion mutations in Saccharomyces cerevisiae.
Genetics
118: 203-212.
Hoffman, C.S. and Winston, F. 1987. A ten-minute DNA preparation from
yeast efficiently releases autonomous plasmids for transformation of Escherichia
coli. Gene
57: 267- 272.
Clark-Adams, C.D. and Winston, F. 1987. SPT6 is an essential gene
required for delta-mediated transcription in Saccharomyces cerevisiae.
Mol.
Cell. Biol. 7: 679-686.
Winston, F., Dollard, C., Malone, E.A., Clare, J., Kapakos, J.G., Farabaugh,
P. and Minehart, P.L. 1987. Three genes are required for trans-activation
of Ty transcription in yeast.
Genetics 115: 649-656.
Winston, F. and Minehart, P.L. 1986. Analysis of the yeast SPT3
gene and identification of its product, a positive regulator of Ty transcription.
Nucl.
Acids Res. 14: 6885-6900.
Winston, F., Durbin, K.J. and Fink, G.R. 1984. The SPT3 gene is
required for normal transcription of Ty elements in S. cerevisiae.
Cell
39: 675-682.
Rose, M. and Winston, F. 1984. Identification of a Ty insertion within
the coding sequence of the S. cerevisiae URA3 gene. Mol.
Gen. Genet. 193: 557-560.
Simchen, G., Winston, F., Styles, C.A. and Fink, G.R. 1984. Ty-mediated
gene expression of the LYS2 and HIS4 genes of Saccharomyces
cerevisiae is controlled by the same SPT genes.
Proc.
Natl. Acad. Sci. USA 81: 2431-2434.
Winston, F., Chaleff, D.T., Valent, B. and Fink, G.R. 1984. Mutations
affecting Ty- mediated expression of the HIS4 gene of Saccharomyces
cerevisiae. Genetics
107: 179-197.
Winston, F. and Botstein, D. 1981. Control of lysogenization by phage
P22. II. Mutations (clyA) in the c1 gene that cause increased
lysogenization. J.
Mol. Biol. 152: 233-245.
Winston, F. and Botstein, D. 1981. Control of lysogenization by phage
P22. I. The P22 cro gene.
J.
Mol. Biol. 152: 209-232.
Winston, F., Botstein, D. and Miller, J.H. 1979. Characterization of amber
and ochre suppressors in Salmonella typhimurium.
J. Bact. 137: 433-439.
Reviews and Books
Sudarsanam, P. and Winston, F. 2000. Recent advances in understanding transcriptional control by the Snf/Swi family of nucleosomes remodeling complexes. Trends in Genetics 16: 345-351.
Winston, F. and Allis, C.D.
1999. The bromodomain: a chromatin-targeting module? Nature Structural
Biology 6: 601-604.
Winston, F. and Sudarsanam, P. 1999. The SAGA of Spt proteins and transcriptional
analysis in yeast: past, present, and future. Cold Spring Harbor Symp.
Quant. Biol. 63: 553-561.
Hartzog, G.A. and Winston. F. 1997. Nucleosomes and transcription: recent
lessons from genetics. Current Opinions in Genetics and Development 7:
192-198.
Winston, F. 1992. Analysis of SPT Genes: A Genetic Approach Towards Analysis
of TFIID, Histones and Other Transcription Factors of Yeast. In, McKnight,
S.L., and Yamamoto, K.R. eds., Transcriptional Regulation, Cold
Spring Harbor Laboratory, Cold Spring Harbor, New York, pp 1271-1293.
Winston, F. and Carlson, M. 1992. Yeast SNF/SWI transcriptional activators
and the SPT/SIN chromatin connection. Trends in Genetics 8: 387-391.
Rose, M.D., Winston, F., and Hieter, P. 1990. Laboratory Course Manual
for Methods in Yeast Genetics. Cold Spring Harbor Laboratory, Cold
Spring Harbor, New York.
Winston, F. 1990. Yeast as a model eukaryotic cell. In, Davis, B.D., Dulbecco,
R., Eisen, H.N. and Ginsberg, H. eds., Microbiology, fourth edition,
J.B. Lippincott, Philadelphia, pp 229-236.
Winston, F. 1988. Transcriptional regulation of Ty elements in Saccharomyces
cerevisiae. In: Liebowitz, M.J. and Koltin, Y., eds., Viruses of
Fungi and Simple Eukaryotes, Marcel Dekker, New York, pp 41-61.
Winston, F. Genes that affect Ty-mediated gene expression in yeast. 1988.
In: Weinstein, I.B., McDonald, J.F., and Lambert, M.E., eds., Banbury
Report 30: Eukaryotic Transposable Elements as Mutagenic Agents. Cold
Spring Harbor Laboratory, Cold Spring Harbor, New York, pp 145 - 153.
Winston, F., Chumley, F.G. and Fink, G.R. 1983. Eviction and transplacement
of mutant genes in yeast. In: Wu, R., Grossman, L. and Moldave, K. (eds.),
Methods in Enzymology: Recombinant DNA, Part B. New York and London, Academic
Press, 101: 211-228.
