The Sinclair Lab studies genes that slow the pace of aging. Work ranges from the isolation of novel stem cells from mouse and humans, to assessing small molecules that slow the pace of aging when fed to mice. Our goal is to uncover new biological processes that can translated into radically different medicines to promote longer, more productive lives. A focus is on the Sirtuin genes and how they they protect against aging and also common diseases such as cancer, heart disease, inflammation, neurodegeneration and diabetes. We have mouse models to assess these diseases and how well genetic and pharmacological agents can slow them. We are expanding into new areas such as understanding how cells control cellular energetics and female fertility, the role of chromatin in DNA repair in aging, and novel genes that control our innate defenses against deterioration and disease. We are a team with complementary skills who work together to solve key scientific questions about mammalian biology and human health. Skills in the lab range from enzymology and biochemistry, to genetics and systems biology, to mouse models and human genetics. A screen of the human genome has recently been completed in collaboration with the Elledge Lab, aimed at identifying mitochondrial enhancers that promote human longevity, opening up entirely new areas of investigation for incoming graduate students.

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