Marjorie Oettinger, Ph.D.

Marjorie Oettinger, Ph.D.
Marjorie Oettinger, Ph.D.
Department of Molecular Biology
Massachusetts General Hospital
Simches CPZN7250
185 Cambridge St
Boston, MA 02114
(617) 726-5967

The various projects in my laboratory are connected by one central theme: we seek to understand all facets of the V(D)J rearrangements that generate diversity within the vertebrate immune system. Specifically we are studying the enzymatic and regulatory machinery involved, the mechanism of the reaction, and the role of chromatin structure in the regulation of recombination events during lymphoid development. In addition, we are interested in how errors in this process lead to various human diseases.