Steven McCarroll, Ph.D.

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Steven McCarroll, Ph.D.
Department of Genetics
Harvard Medical School
NRB 260J
77 Avenue Louis Pasteur
Boston, MA 02115
(617) 432-7794

The scientists in my lab work to understand (i) how the human genome varies from person to person, and (ii) how inherited genome variation affects the biology of neurons and microglia on its way to affecting brain illnesses such as schizophrenia, autism and bipolar disorder. Most projects in the lab draw upon both molecular and computational analysis. A key interest is in developing novel molecular and computational approaches that allow us to appreciate new kinds of things about genomes and biological systems. Some of our recent papers have been about new ways to analyze somatic mutations and DNA replication from sequence data, leading to discoveries of a common, pre-cancerous state in the blood and ways in which DNA sequence variation affects DNA replication. We recently developed a technology (Drop-Seq) for profiling RNA expression genome-wide in tens of thousands of individual cells at once, and are now working to develop both new applications for Drop-Seq and new computational approaches for deriving biological insight from such data. We hope to understand brain function and dysfunction in terms of the distinct responses of thousands of individual cells of diverse types.