Jeannie T. Lee, M.D., Ph.D.

Jeannie T. Lee, M.D., Ph.D.
Jeannie T. Lee, M.D., Ph.D.
Department of Molecular Biology
Massachusetts General Hospital
Simches 6.624
185 Cambridge St
Boston, MA 02114
(617) 643-3043

Our lab studies how male (XY) and female (XX) cells use a mechanism called X-chromosome inactivation to achieve equality of sex chromosome gene expression. Our studies are focused on three noncoding RNA loci whose actions coordinate the many steps of X-chromosome inactivation. We are also interested in the mechanistic and evolutionary relationship between X inactivation and imprinting. Recent work by the Lee Lab suggests that imprinted X-chromosome inactivation is directly connected to meiotic sex chromosome inactivation in the male germline.