Stephen J. Elledge, Ph.D.

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Stephen J. Elledge, Ph.D.
Department of Genetics
Harvard Medical School
NRB 158D
77 Avenue Louis Pasteur
Boston, MA 02115
(617) 525-4510

We study the cellular response to genotoxic stress. We have uncovered a signal transduction protein kinase cascade that phosphorylates over 700 proteins in response to DNA damage and controls genomic stability. Using synthetic biology we also develop genetic technologies such as genome-wide viral libraries of shRNAs for genetic screening in mammals to identify genes important for cancer and growth control.