Christine Seidman, M.D.

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Christine Seidman, M.D.
Department of Genetics
Harvard Medical School
NRB 0256
77 Avenue Louis Pasteur
Boston, MA 02115
(617) 432-7830

Christine Seidman is interested in dominant-acting mutations in sarcomere protein genes that cause hypertrophic cardiomyopathy in humans. The Seidman lab has made a murine model of this disease and demonstrated that these mutations lead to altered Ca2+ concentrations in myocytes. Ca2+ channel blockers reduce the hypertrophic response to sarcomere protein gene mutations in mice.