Monica P. Colaiacovo, Ph.D.

We are investigating mechanisms underlying germline maintenance and accurate meiotic chromosome segregation at the molecular level. We are exploring meiotic chromosome dynamics, particularly, the interplay between changes in chromosome configuration/structure during meiosis, and homologous chromosome pairing, synapsis, and DNA double-strand break repair. We are also investigating the roles of histone demethylases in germline maintenance and double-strand break repair. Our studies combine genetic, cytological, biochemical and molecular biology approaches in the nematode C. elegans.