Jae-Hyun Yang, Ph.D.

Post-doctoral Fellow

Jae-Hyun YangThere is increasing evidence that aging is at least in part due to epigenetic alterations over time that lead to cellular dysfunction. I am studying whether the cellular response to environmental stimuli and stress creates epigenetic memory of previous events and how it contributes to age-associated gene expression changes that ultimately lead to cellular dysfunction. The details of the molecular mechanisms at work are being studied by genome-wide observation of epigenetic dynamics in response to transient generation and repair of a few DNA double-strand breaks within non-coding regions of the genome. Ultimately I aim to determine whether it is possible to reverse the epigenetic memory to the pre-insult state.


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