Research Interest: To better understand how aging occurs at the cellular level, I am utilizing cells derived from our inducible rapid aging mouse model (ICE mice) to generate iPS cells. These can be differentiated into a variety of cell types and then induced to age. This method allows for the study of aging and age-related diseases in varied and specific cell types that may be otherwise difficult to obtain or maintain in culture. In addition I am studying the reprograming process in iPSCs to determine if it could be applied to normal aging cells for the purpose of delaying or reversing aging. Motivated by evidence suggesting that modulation of SIRT6 levels may greatly impact aging and longevity, I am also studying SIRT6 function and screening for small molecules that could potentiate SIRT6 activity.