Giuseppe Coppotelli, Ph.D.

Post-doctoral Fellow

Giuseppe CoppotelliMy research efforts are directed toward dissecting the underlying molecular mechanisms of the aging process and discovering novel markers and treatments that could predict and ameliorate aging as well as age-associated diseases. My work aims to determine the cause of the protein homeostasis dysregulation observed in aging, focusing on the ubiquitin proteasome and autophagy lysosome systems. In particular, I am investigating the interconnectedness of protein homeostasis dysregulation with mitochondrial dysfunction, and the effect that cellular redox status, ATP/ADP, and NAD+/NADH levels have on the molecular machinery used for protein degradation. I am also interested in understanding the role of dysfunctional mitochondria and dysregulation of proteostasis with inflammation.


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