Giuseppe Coppotelli, Ph.D.

Post-doctoral Research Fellow

Giuseppe CoppotelliResearch Interest: My research efforts are directed toward dissecting the underlying molecular mechanisms of the aging process and discovering novel markers and treatments that could predict and ameliorate aging as well as age-associated diseases. My work aims to determine the cause of the protein homeostasis dysregulation observed in aging, focusing on the ubiquitin proteasome and autophagy lysosome systems. In particular, I am investigating the interconnectedness of protein homeostasis dysregulation with mitochondrial dysfunction, and the effect that cellular redox status, ATP/ADP, and NAD+/NADH levels have on the molecular machinery used for protein degradation. I am also interested in understanding the role of dysfunctional mitochondria and dysregulation of proteostasis with inflammation.

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