Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

Basil P. Hubbard, et al.
Science, March 8, 2013

 

As a way to control DNA repair, apoptosis, circadian clocks, inflammatory pathways, insulin secretion, and activation of mitochondria, SIRT1 has been implicated in preventing age-related diseases. Activation of SIRT1 by resveratrol has been studied as a cause of prolonged lifespan in mice. Based on this research, David Sinclair and Sirtris Pharmaceuticals have developed synthetic activators of SIRT1 that are currently in clinical trials.

David Sinclair, Basil Hubbard, and colleagues present evidence for a common mechanism by which sirtuin-activating compounds (STACs), including resveratrol and the synthetic activators developed by Sirtris, activate SIRT1.