Activity Regulated Transcription
A stylized rendering of ChIP-Seq and RNA-Seq data revealing transcriptional upregulation at and near the Fos locus.
Photo Credit to Helen Yang
How do transcriptional networks rewire neuronal circuits?
Our work approaches this question from two angles. First, we use genomic approaches to study how changes in neuronal activity are translated into the kinds of transcriptional responses that can rewire neural circuits. Above is a stylized rendering of ChIP-Seq and RNA-Seq data revealing transcriptional upregulation at and near the Fos locus (see our publications for details). Second, we are developing new strategies for using transcriptional reporters of activity to identify neural circuits underlying remote memory formation, with the ultimate goal of identifying precise functions of activity-regulated transcripts in memory consolidation.
The work of science is limitless. We are always looking for enthusiastic collaborators.
(617) 432-1877 [office]
(617) 432-1925 [lab]
Gray Lab, Department of Genetics, Harvard Medical School
NRB 0356, 77 Avenue Louis Pasteur, Boston, MA 02115