Activity Regulated Transcription
A stylized rendering of ChIP-Seq and RNA-Seq data revealing transcriptional upregulation at and near the Fos locus.
Photo Credit to Helen Yang
How do transcription networks rewire neuronal circuits?
The goal of our laboratory is to understand the contribution of neuronal activity-regulated transcription to long-term memory formation. To achieve this goal, we study how neuronal activity regulates transcription, and how transcription in turn regulates neuronal activity and circuit plasticity.
What does it tell us about a neuron’s activity history that it expresses an activity-regulated gene like Fos?
How are transcriptomic computations encoded in neuronal signaling pathways and regulatory sequences?
How does activity-regulated transcription contribute to long-term plasticity and memory formation in the mouse neocortex?
The work of science is limitless. We are always looking for enthusiastic collaborators.
(617) 432-1877 [office]
(617) 432-1925 [lab]