David M. Livingston, M.D.

 My laboratory works on the elucidation of pathways that are controlled by a growing family of breast and ovarian cancer suppressor genes. This family, which includes BRCA1 and 2,  encode proteins that, at a minimum, contribute to the normal cellular responses to DNA damage and to genome integrity control, in general. In particular, we have emphasized an effort to understand how the functions of these gene products contribute to breast and ovarian cancer suppression, in particular.